| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1959 | 9/25 | R. J. Reynolds, NC | 7 | 27 | L | 1 | Home | Roanoke | Victory Stadium | Fred Smith | ||||
| 1960 | 9/24 | R. J. Reynolds, NC | 7 | 13 | L | 1 | Away | Winston-Salem | Fred Smith | |||||
| 2011 | 9/23 | R. J. Reynolds, NC | 14 | 27 | L | 1 | Away | Winston-Salem | Lee Johnson | |||||
| 2012 | 9/21 | R. J. Reynolds, NC | 13 | 14 | L | 1 | Home | Roanoke | Fleming Field | Lee Johnson | ||||
| 41 | 81 | 0 | 4 | 0 | .000 | |||||||||
| 10.25 | 20.25 | -10.00 | ||||||||||||