| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1938 | 9/17 | William Fleming | 14 | 0 | W | 1 | Home | Salem | Municipal Stadium | Ducky Denton | ||||
| 1939 | 9/16 | William Fleming | 26 | 7 | W | 1 | Home | Salem | Municipal Stadium | Ducky Denton | ||||
| 1940 | 10/4 | William Fleming | 47 | 7 | W | 1 | Home | Salem | Roanoke College | Ducky Denton | first night game | |||
| 1941 | 9/27 | William Fleming | 13 | 0 | W | 1 | Home | Salem | Roanoke College | Ducky Denton | ||||
| 1942 | 9/28 | William Fleming | 0 | 6 | L | 1 | Home | Salem | Roanoke College | Charley Turner | ||||
| 1943 | 10/15 | William Fleming | 13 | 7 | W | 1 | Home | Salem | Roanoke College | Jim Peters | ||||
| 1943 | 11/6 | William Fleming | 0 | 0 | T | 1 | Away | Roanoke | Fleming Field | Jim Peters | ||||
| 1944 | 10/6 | William Fleming | 7 | 6 | W | 1 | Home | Salem | Roanoke College | Pinky Spruhan | ||||
| 1945 | 10/12 | William Fleming | 0 | 14 | L | 1 | Home | Salem | Roanoke College | Pinky Spruhan | ||||
| 1946 | 10/11 | William Fleming | 32 | 0 | W | 1 | Home | Salem | Municipal Stadium | Pinky Spruhan | ||||
| 1947 | 11/21 | William Fleming | 0 | 7 | L | 1 | Home | Salem | Municipal Stadium | Pinky Spruhan | postponed from 10-10 | |||
| 1948 | 10/8 | William Fleming | 12 | 0 | W | 1 | Home | Salem | Municipal Stadium | Pinky Spruhan | ||||
| 1949 | 10/8 | William Fleming | 0 | 0 | T | 1 | Home | Salem | Municipal Stadium | Pinky Spruhan | ||||
| 1950 | 10/13 | William Fleming | 0 | 6 | L | 1 | Home | Salem | Municipal Stadium | Pinky Spruhan | ||||
| 1951 | 10/12 | William Fleming | 14 | 19 | L | 1 | Home | Salem | Municipal Stadium | Hal Johnston | ||||
| 1952 | 10/11 | William Fleming | 7 | 34 | L | 1 | Home | Salem | Municipal Stadium | Hal Johnston | ||||
| 1953 | 10/9 | William Fleming | 12 | 6 | W | 1 | Home | Salem | Municipal Stadium | Hal Johnston | ||||
| 1954 | 10/8 | William Fleming | 6 | 20 | L | 1 | Home | Salem | Municipal Stadium | Hal Johnston | ||||
| 1955 | 10/15 | William Fleming | 13 | 20 | L | 1 | Home | Salem | Municipal Stadium | Hal Johnston | postponed | |||
| 1956 | 10/12 | William Fleming | 0 | 14 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1957 | 10/10 | William Fleming | 0 | 7 | L | 1 | Home | Salem | Salem Municipal Stadium | Hal Johnston | ||||
| 1958 | 10/10 | William Fleming | 12 | 21 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1959 | 11/13 | William Fleming | 0 | 34 | L | 1 | Home | Salem | Municipal Stadium | Hal Johnston | postponed from 10-8 | |||
| 1960 | 10/7 | William Fleming | 13 | 20 | L | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1961 | 10/6 | William Fleming | 7 | 0 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1962 | 10/12 | William Fleming | 0 | 1 | L | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | forfeit - original score 14-0 | |||
| 1963 | 10/11 | William Fleming | 7 | 6 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1964 | 10/9 | William Fleming | 39 | 13 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1965 | 10/8 | William Fleming | 13 | 0 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1966 | 10/14 | William Fleming | 9 | 6 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1967 | 10/13 | William Fleming | 33 | 0 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1968 | 10/21 | William Fleming | 14 | 0 | W | 1 | Away | Roanoke | Viking Stadium | Eddie Joyce | ||||
| 1969 | 10/17 | William Fleming | 14 | 0 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1970 | 10/16 | William Fleming | 0 | 28 | L | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1971 | 10/15 | William Fleming | 19 | 14 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1972 | 10/20 | William Fleming | 37 | 0 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1973 | 10/19 | William Fleming | 24 | 14 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1974 | 9/27 | William Fleming | 13 | 19 | L | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1975 | 9/26 | William Fleming | 22 | 21 | W | 1 | Away | Roanoke | Victory Stadium | Mike Stevens | ||||
| 1976 | 9/24 | William Fleming | 14 | 7 | W | 1 | Home | Salem | Municipal Stadium | Mike Stevens | ||||
| 1977 | 9/17 | William Fleming | 17 | 14 | W | 1 | Away | Roanoke | Victory Stadium | Tom Kucer | postponed | |||
| 1978 | 9/15 | William Fleming | 15 | 13 | W | 1 | Away | Roanoke | Victory Stadium | Tom Kucer | ||||
| 1979 | 9/21 | William Fleming | 8 | 6 | W | 1 | Home | Salem | Salem Stadium | Wallace Thompson | ||||
| 1980 | 9/19 | William Fleming | 0 | 48 | L | 1 | Away | Roanoke | Victory Stadium | Wallace Thompson | ||||
| 1981 | 9/18 | William Fleming | 7 | 14 | L | 1 | Home | Salem | Salem Stadium | Wallace Thompson | ||||
| 1982 | 9/17 | William Fleming | 8 | 6 | W | 1 | Away | Roanoke | Victory Stadium | Carl Richards, Jr. | ||||
| 1983 | 9/16 | William Fleming | 12 | 34 | L | 1 | Home | Salem | Salem Stadium | Willis White | ||||
| 1984 | 9/21 | William Fleming | 16 | 9 | W | 1 | Away | Roanoke | Victory Stadium | Willis White | ||||
| 1985 | 9/20 | William Fleming | 6 | 0 | W | 1 | Home | Salem | Salem Stadium | Willis White | ||||
| 1986 | 9/19 | William Fleming | 35 | 0 | W | 1 | Away | Roanoke | Victory Stadium | Willis White | ||||
| 1987 | 9/18 | William Fleming | 15 | 14 | W | 1 | Home | Salem | Salem Stadium | Willis White | ||||
| 2001 | 9/14 | William Fleming | 10 | 7 | W | 1 | Home | Salem | Salem Stadium | Willis White | ||||
| 2002 | 9/13 | William Fleming | 6 | 14 | L | 1 | Away | Roanoke | Fleming Field | Willis White | ||||
| 2003 | 9/26 | William Fleming | 26 | 7 | W | 1 | Home | Salem | Salem Stadium | Willis White | ||||
| 2004 | 10/1 | William Fleming | 21 | 10 | W | 1 | Away | Roanoke | Fleming Field | Steve Magenbauer | ||||
| 2005 | 9/30 | William Fleming | 14 | 6 | W | 1 | Home | Salem | Salem Stadium | Steve Magenbauer | ||||
| 2006 | 9/29 | William Fleming | 28 | 0 | W | 1 | Away | Roanoke | Fleming Field | Steve Magenbauer | ||||
| 2006 | 11/17 | William Fleming | 17 | 14 | W | 1 | Home | Salem | Salem Stadium | Steve Magenbauer | playoff at Salem | |||
| 2007 | 9/28 | William Fleming | 27 | 14 | W | 1 | Home | Salem | Salem Stadium | Steve Magenbauer | ||||
| 2008 | 9/26 | William Fleming | 23 | 19 | W | 1 | Away | Roanoke | Patriot Stadium | Steve Magenbauer | ||||
| 2009 | 10/2 | William Fleming | 27 | 0 | W | 1 | Home | Salem | Salem Stadium | Steve Magenbauer | ||||
| 2010 | 10/1 | William Fleming | 27 | 21 | W | 1 | Away | Roanoke | Fleming Field | Steve Magenbauer | ||||
| 2011 | 9/30 | William Fleming | 21 | 0 | W | 1 | Home | Salem | Salem Stadium | Steve Magenbauer | ||||
| 2012 | 9/28 | William Fleming | 31 | 6 | W | 1 | Away | Roanoke | Fleming Field | Steve Magenbauer | ||||
| 2021 | 9/10 | William Fleming | 46 | 20 | W | 1 | Away | Roanoke | Fleming Field | Don Holter | ||||
| 2022 | 9/9 | William Fleming | 49 | 12 | W | 1 | Home | Salem | Salem Stadium | Don Holter | ||||
| 2023 | 9/8 | William Fleming | 33 | 14 | W | 1 | Away | Roanoke | Fleming Field | Don Holter | ||||
| 2024 | 9/13 | William Fleming | 7 | 25 | L | 1 | Home | Salem | Salem Stadium | Don Holter | ||||
| 2025 | 9/12 | William Fleming | 13 | 34 | L | 1 | Away | Roanoke | Fleming Field | Don Holter | ||||
| 2026 | 9/11 | William Fleming | 45 | 12 | W | 1 | Home | Salem | Salem Stadium | Don Holter | ||||
| 1,116 | 777 | 46 | 22 | 2 | .671 | |||||||||
| 15.94 | 11.10 | 4.84 | ||||||||||||