| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1986 | 8/29 | Blacksburg | 7 | 14 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Jerry Little | ||||
| 1987 | 8/28 | Blacksburg | 13 | 10 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Jerry Little | ||||
| 1994 | 9/16 | Blacksburg | 12 | 7 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Steve Spangler | ||||
| 1995 | 9/15 | Blacksburg | 14 | 7 | W | 1 | 1OT | Home | Roanoke | Dwight Bogle Stadium | Steve Spangler | |||
| 1996 | 9/13 | Blacksburg | 14 | 16 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Steve Spangler | ||||
| 1997 | 9/12 | Blacksburg | 56 | 7 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Steve Spangler | ||||
| 1998 | 9/11 | Blacksburg | 6 | 13 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Steve Spangler | ||||
| 1999 | 9/10 | Blacksburg | 27 | 6 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Ben Foutz | ||||
| 2000 | 9/8 | Blacksburg | 0 | 1 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Ben Foutz | forfeit - original score 14-6 | |||
| 2003 | 10/10 | Blacksburg | 6 | 26 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Ben Foutz | ||||
| 2004 | 10/15 | Blacksburg | 35 | 7 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Ben Foutz | ||||
| 2005 | 10/14 | Blacksburg | 27 | 16 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2006 | 10/13 | Blacksburg | 0 | 32 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2007 | 10/12 | Blacksburg | 0 | 40 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2008 | 10/10 | Blacksburg | 14 | 28 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Tim Fulton | ||||
| 2009 | 10/23 | Blacksburg | 27 | 19 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2010 | 10/22 | Blacksburg | 49 | 21 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Tim Fulton | ||||
| 2011 | 10/21 | Blacksburg | 40 | 6 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2012 | 10/19 | Blacksburg | 21 | 14 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Tim Fulton | ||||
| 2013 | 11/1 | Blacksburg | 27 | 24 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Tim Fulton | ||||
| 2014 | 10/31 | Blacksburg | 34 | 35 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2015 | 10/23 | Blacksburg | 14 | 20 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2016 | 10/22 | Blacksburg | 23 | 35 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Tim Fulton | ||||
| 2017 | 10/6 | Blacksburg | 7 | 49 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2018 | 10/5 | Blacksburg | 0 | 29 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Tim Fulton | ||||
| 2019 | 10/11 | Blacksburg | 3 | 55 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2021 | 3/5 | Blacksburg | 34 | 7 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Tim Fulton | ||||
| 2021 | 11/5 | Blacksburg | 21 | 14 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Nick Leftwich | ||||
| 2022 | 11/3 | Blacksburg | 41 | 10 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Nick Leftwich | ||||
| 2023 | 9/22 | Blacksburg | 38 | 7 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Hunter Shepherd | ||||
| 2024 | 9/30 | Blacksburg | 13 | 27 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Hunter Shepherd | postponed from 9-27 | |||
| 2025 | 10/3 | Blacksburg | 15 | 12 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Hunter Shepherd | ||||
| 2026 | 10/1 | Blacksburg | 27 | 34 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Hunter Shepherd | ||||
| 665 | 648 | 17 | 16 | 0 | .515 | |||||||||
| 20.15 | 19.64 | 0.52 |