| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Place | Stadium | Coach | Notes |
| 2009 | 11/20 | St. Xavier | 34 | 48 | L | 1 | Away | Louisville | Jeff Marksberry | playoff at Louisville | ||||
| 2024 | 11/8 | St. Xavier | 13 | 48 | L | 1 | Away | Louisville | Roy Lucas, Jr. | playoff at Louisville | ||||
| 47 | 96 | 0 | 2 | 0 | .000 | |||||||||
| 23.50 | 48.00 | -24.50 |