| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1988 | 9/23 | Louisville | 13 | 20 | L | 1 | Home | Wooster | Mauer Field | Bob McFarland | |||||
| 1989 | 9/15 | Louisville | 20 | 6 | W | 1 | Away | Louisville | Bob McFarland | ||||||
| 2020 | 10/2 | Louisville | 12 | 7 | W | 1 | Away | Louisville | Doug Haas | ||||||
| 2021 | 9/3 | Louisville | 16 | 14 | W | 1 | Away | Louisville | Austin Holter | ||||||
| 2024 | 10/25 | Louisville | 17 | 28 | L | 1 | Home | Wooster | Follis Field | Austin Holter | |||||
| 2025 | 10/24 | Louisville | 7 | 50 | L | 1 | Home | Wooster | Follis Field | Ray Leek | |||||
| 85 | 125 | 3 | 3 | 0 | .500 | ||||||||||
| 14.17 | 20.83 | 6.67 |