| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1910 | Wheeling Central Catholic, WV | 5 | 5 | T | 1 | N. E. Miller | |||||||||
| 1917 | 11/3 | Wheeling Central Catholic, WV | 27 | 6 | W | 1 | Home | Steubenville | John Brandt | ||||||
| 2008 | 10/17 | Wheeling Central Catholic, WV | 47 | 22 | W | 1 | Home | Steubenville | Harding Stadium | Reno Saccoccia | |||||
| 79 | 33 | 2 | 0 | 1 | .833 | ||||||||||
| 26.33 | 11.00 | 15.33 |