| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1926 | 9/25 | Louisville | 12 | 0 | W | 1 | Home | Salem | Reilly Stadium | Wilbur Springer | |||||
| 1927 | 9/24 | Louisville | 6 | 9 | L | 1 | Away | Louisville | Wilbur Springer | ||||||
| 1928 | 9/22 | Louisville | 35 | 13 | W | 1 | Home | Salem | Reilly Stadium | Floyd Stone | |||||
| 1992 | 9/18 | Louisville | 8 | 27 | L | 1 | Home | Salem | Reilly Stadium | Rich Washinko | |||||
| 1993 | 9/17 | Louisville | 20 | 39 | L | 1 | Away | Louisville | Rich Washinko | ||||||
| 2011 | 10/21 | Louisville | 7 | 21 | L | 1 | Away | Louisville | Mike Kopachy | ||||||
| 2012 | 10/19 | Louisville | 26 | 43 | L | 1 | Home | Salem | Reilly Stadium | Ron Johnson | |||||
| 2013 | 9/20 | Louisville | 28 | 41 | L | 1 | Away | Louisville | Ron Johnson | ||||||
| 2014 | 9/19 | Louisville | 6 | 49 | L | 1 | Home | Salem | Reilly Stadium | Ron Johnson | |||||
| 2015 | 10/23 | Louisville | 10 | 40 | L | 1 | Away | Louisville | Ron Johnson | ||||||
| 2016 | 10/21 | Louisville | 27 | 46 | L | 1 | Home | Salem | Reilly Stadium | Ron Johnson | |||||
| 2017 | 10/20 | Louisville | 43 | 35 | W | 1 | Away | Louisville | Ron Johnson | ||||||
| 228 | 363 | 3 | 9 | 0 | .250 | ||||||||||
| 19.00 | 30.25 | -11.25 | |||||||||||||