| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1937 | 10/1 | St. Xavier | 7 | 26 | L | 1 | Away | Louisville | Maxwell Field | W. M. Messer | ||||
| 1948 | 10/1 | St. Xavier | 0 | 46 | L | 1 | Away | Louisville | Manuel Stadium | Ted Benedett | ||||
| 7 | 72 | 0 | 2 | 0 | .000 | |||||||||
| 3.50 | 36.00 | -32.50 | ||||||||||||