| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1908 | Jefferson, Sr. | 0 | 51 | L | 1 | |||||||||
| 1909 | Jefferson, Sr. | 0 | 10 | L | 1 | |||||||||
| 1910 | 10/26 | Jefferson, Sr. | 0 | 5 | L | 1 | Away | Roanoke | Fairgrounds | |||||
| 1916 | 9/29 | Jefferson, Sr. | 0 | 10 | L | 1 | Home | Salem | ||||||
| 1917 | 10/19 | Jefferson, Sr. | 9 | 7 | W | 1 | Away | Roanoke | Fairgrounds | Pinky Spruhan | ||||
| 1920 | 10/16 | Jefferson, Sr. | 0 | 7 | L | 1 | Home | Salem | Roanoke College | Leary | ||||
| 1921 | 10/29 | Jefferson, Sr. | 0 | 20 | L | 1 | Away | Roanoke | Fairgrounds | Pinky Spruhan | ||||
| 1922 | 10/28 | Jefferson, Sr. | 0 | 6 | L | 1 | Home | Salem | Roanoke College | L. E. Kibler | ||||
| 1926 | 10/16 | Jefferson, Sr. | 0 | 14 | L | 1 | Home | Salem | Roanoke College | Gordon White | ||||
| 1927 | 10/29 | Jefferson, Sr. | 6 | 18 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1928 | 11/2 | Jefferson, Sr. | 0 | 6 | L | 1 | Home | Salem | Roanoke College | Ducky Denton | ||||
| 1929 | 11/16 | Jefferson, Sr. | 6 | 6 | T | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1930 | 11/15 | Jefferson, Sr. | 0 | 6 | L | 1 | Home | Salem | Ducky Denton | |||||
| 1931 | 10/10 | Jefferson, Sr. | 7 | 14 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1932 | 10/15 | Jefferson, Sr. | 0 | 0 | T | 1 | Home | Salem | Ducky Denton | |||||
| 1933 | 10/14 | Jefferson, Sr. | 20 | 6 | W | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1934 | 10/13 | Jefferson, Sr. | 0 | 7 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1935 | 10/12 | Jefferson, Sr. | 0 | 20 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1936 | 10/10 | Jefferson, Sr. | 0 | 7 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1937 | 10/30 | Jefferson, Sr. | 6 | 2 | W | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1938 | 11/5 | Jefferson, Sr. | 0 | 7 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1939 | 10/7 | Jefferson, Sr. | 6 | 13 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1940 | 10/26 | Jefferson, Sr. | 15 | 7 | W | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1941 | 10/25 | Jefferson, Sr. | 6 | 25 | L | 1 | Away | Roanoke | Maher Field | Ducky Denton | ||||
| 1942 | 10/24 | Jefferson, Sr. | 0 | 35 | L | 1 | Away | Roanoke | Victory Stadium | Charley Turner | ||||
| 1943 | 10/23 | Jefferson, Sr. | 0 | 27 | L | 1 | Away | Roanoke | Victory Stadium | Jim Peters | ||||
| 1944 | 10/28 | Jefferson, Sr. | 7 | 21 | L | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | ||||
| 1945 | 10/26 | Jefferson, Sr. | 0 | 25 | L | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | Guy | |||
| 1946 | 10/26 | Jefferson, Sr. | 0 | 0 | T | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | ||||
| 1947 | 10/24 | Jefferson, Sr. | 0 | 22 | L | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | ||||
| 1948 | 10/22 | Jefferson, Sr. | 14 | 21 | L | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | ||||
| 1949 | 10/21 | Jefferson, Sr. | 0 | 35 | L | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | ||||
| 1950 | 10/27 | Jefferson, Sr. | 0 | 26 | L | 1 | Away | Roanoke | Victory Stadium | Pinky Spruhan | ||||
| 1951 | 10/26 | Jefferson, Sr. | 0 | 14 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1952 | 10/24 | Jefferson, Sr. | 0 | 25 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1953 | 10/23 | Jefferson, Sr. | 13 | 14 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1954 | 10/22 | Jefferson, Sr. | 6 | 28 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1955 | 10/28 | Jefferson, Sr. | 13 | 20 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1956 | 11/20 | Jefferson, Sr. | 7 | 26 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | postponed from 10-26 | |||
| 1957 | 10/25 | Jefferson, Sr. | 0 | 26 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1958 | 10/24 | Jefferson, Sr. | 13 | 13 | T | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1959 | 10/24 | Jefferson, Sr. | 6 | 43 | L | 1 | Away | Roanoke | Victory Stadium | Hal Johnston | ||||
| 1960 | 10/21 | Jefferson, Sr. | 0 | 7 | L | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1961 | 10/21 | Jefferson, Sr. | 21 | 0 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | postponed | |||
| 1962 | 10/26 | Jefferson, Sr. | 0 | 1 | L | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | forfeit - original score 6-0 | |||
| 1963 | 10/25 | Jefferson, Sr. | 28 | 19 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1964 | 10/23 | Jefferson, Sr. | 31 | 6 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1965 | 10/22 | Jefferson, Sr. | 26 | 13 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1966 | 9/23 | Jefferson, Sr. | 40 | 6 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1967 | 9/22 | Jefferson, Sr. | 28 | 0 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1968 | 9/28 | Jefferson, Sr. | 7 | 12 | L | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1969 | 9/26 | Jefferson, Sr. | 19 | 22 | L | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1970 | 9/26 | Jefferson, Sr. | 29 | 6 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1971 | 9/24 | Jefferson, Sr. | 21 | 6 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 1972 | 9/30 | Jefferson, Sr. | 41 | 0 | W | 1 | Away | Roanoke | Victory Stadium | Eddie Joyce | ||||
| 1973 | 9/28 | Jefferson, Sr. | 46 | 29 | W | 1 | Home | Salem | Municipal Stadium | Eddie Joyce | ||||
| 497 | 822 | 14 | 38 | 4 | .286 | |||||||||
| 8.88 | 14.68 | -5.80 |